Pawanax Research

We study the systems that keep people alive.

Clinical AI, African languages, epidemic intelligence, forecasting and the economics of health. We publish our methods, our results and our forecasts, and we score those forecasts in public.

In one paragraph

Pawanax Research is the research group of Pawanax AI. We study clinical AI and safety, language intelligence for more than 50 African languages, epidemic intelligence through Epicenter surveillance, forecasting and decision science, health economics including remittance flows, and critical minerals and industrial policy. The group is led by Dr. Fidelis Ndombera, PhD, whose six peer-reviewed publications cover cancer biology, medicinal chemistry and COVID-19 cheminformatics. We publish methods and results, not proprietary model internals, and we register forecasts in advance and score them with the Brier score.

Live lab instruments

What the platform is doing today

As of

1,776

internship & academy applications

1,755 in the last 90 days

12,158

WhatsApp agent messages handled

across 167 user profiles

5,329

epidemic-surveillance alerts generated

from 24 monitored data sources

259

registered platform accounts

plus 82 stablecoin wallets

Research areas

Six questions we keep returning to

Clinical AI & safety

Decision support for clinicians and families, evaluated per task on quality, safety and cost. Pawanax supports care; it does not replace a doctor, and urgent symptoms are escalated to human care.

Questions we are asking

  • Where does a clinical AI system fail, and how do we detect the failure before a patient is harmed?
  • What does clinician oversight need to look like to be useful rather than ceremonial?

African language intelligence

Understanding and generation across more than 50 African languages, so that people can ask about their health in the language they think in.

Questions we are asking

  • How much performance is lost when moving from a major language to a low-resource one?
  • Which health vocabulary breaks first in translation, and how do we test for it?

Epidemic intelligence

Epicenter surveillance turns scattered public and local signals into alerts for public-health teams. So far it has generated 5,329 alerts from 24 monitored data sources.

Questions we are asking

  • Which early signals actually precede a confirmed outbreak, and by how long?
  • How do we keep alert volume low enough that a person will still read every one?

Forecasting & decision science

Probabilities stated in advance and scored when they resolve. We track calibration, not confidence, and we publish the forecasts we get wrong.

Questions we are asking

  • When a forecast misses, is the fault in the model, the data, or the question?
  • How should a budget holder act on a probability of 0.4?

Health economics & remittance

How money moves into and out of health. Kenya's formal remittances reached $5.04B in 2025, and 12.5% of that value goes to medical care.

Questions we are asking

  • How much of a remittance dollar is lost to fees before it reaches a family?
  • Can a health fund attached to a transfer change where care is bought?

Critical minerals & industrial policy

How mineral value is captured locally or exported raw, and what industrial policy can do about it. Work in this area runs through Matawis.

Questions we are asking

  • What share of mineral value stays in the producing country under current contracts?
  • Which downstream processing steps are realistic within a decade?

Library

Download the papers

Working papers, theses, forecasts and protocols from the lab. Each PDF is the version we stand behind, with its date and version noted on the card.

Featured

ForecastForecasting

World State 2026: Stress, Adaptation, Opportunity

A scenario forecast across economics, geopolitics, technology, science and psychology at 3, 6 and 9 months and 1, 2 and 3 years

Authors
Matawis AI, Pawanax AI
Published
Oct 2026
Pages
53
Size
6.6 MB

A reproducible scenario model of the world as of 13 October 2026. It separates observed, preliminary, forecast and judgment-based evidence, simulates five pathways with correlated monthly shocks (100,000 draws), registers dated hazard probabilities, and translates the result into a ranked register of 40 commercial opportunities for Kenya and East Africa. Its limits are stated plainly: the model is reproducible but not yet calibrated, and it proposes a Brier-score protocol to earn an accuracy claim.

  • scenario modelling
  • Monte Carlo
  • Kenya
  • energy

3 papers

ThesisPolicy

Kenya Vision 2060: Sovereign Intelligence

An operating thesis for turning abundant machine intelligence into Kenyan-owned physical prosperity

Authors
Derrick Macharia
Published
Aug 2026
Pages
56
Size
7.5 MB

A 56-page founder thesis on how Kenya can convert increasingly capable and inexpensive machine intelligence into durable national prosperity across energy, agrifood, cyber trust, programmable settlement and regional infrastructure, with measurable dashboards for debt service, reliable power, productivity, export complexity, household welfare and domestic capital ownership.

  • Kenya
  • sovereign AI
  • industrial policy
  • Vision 2060
PaperMinerals

Verified Processing Evidence for Critical Mineral Investment Decisions

A decision framework with reproducible simulation diagnostics and a prospective Kenyan fluorspar validation study

Authors
Derrick Macharia
Published
Oct 2026
Pages
10
Size
0.4 MB

A methods and simulation study proposing how investors and governments can weigh evidence that minerals were actually processed where claimed. It combines three evidence layers across 20,000 simulated paths and five conditions, reports failure modes rather than hiding them inside a single accuracy score, and pre-specifies a prospective field validation on Kenyan fluorspar. Data are synthetic; field validation and buyer adoption remain prospective.

  • critical minerals
  • processing in place
  • simulation
  • fluorspar
White paperClinical AI

Pawanax AI: The AI Operating System for African Healthcare

Clinical intelligence, WhatsApp access, disease surveillance and instant settlement on one platform

Authors
Pawanax AI
Published
Jul 2026
Pages
7
Size
6.5 MB

A short whitepaper describing how Pawanax connects clinicians, patients, surveillance and payments: phone-native access with zero install, clinician-facing intelligence, outbreak signal monitoring and a settlement rail, designed around the way healthcare already works in Africa.

  • platform
  • WhatsApp
  • surveillance
  • payments

Peer-reviewed work by our team

Publications

View full record on Google Scholar
  1. Journal of Pharmacy and Pharmacology · 2019

    Pharmacokinetic, physicochemical and medicinal properties of n-glycoside anti-cancer agent more potent than 2-deoxy-d-glucose in lung cancer cells

    F Ndombera, G Maiyoh, V Tuei

    Abstract

    Reports the pharmacokinetic, physicochemical and medicinal-property profile of an n-glycoside anti-cancer agent, and compares its activity with 2-deoxy-d-glucose in lung cancer cell lines.

    51citations

    Google Scholar
  2. Molecular BioSystems · 2016

    A clickable glutathione approach for identification of protein glutathionylation in response to glucose metabolism

    KTG Samarasinghe, DNPM Godage, Y Zhou, FT Ndombera, E Weerapana, YH Ahn

    Abstract

    Describes a clickable glutathione approach for identifying protein glutathionylation in cells responding to changes in glucose metabolism.

    40citations

    Google Scholar
  3. Bioorganic & Medicinal Chemistry Letters · 2016

    Carbohydrate-based inducers of cellular stress for targeting cancer cells

    FT Ndombera, GC VanHecke, S Nagi, YH Ahn

    Abstract

    Examines carbohydrate-based compounds designed to induce cellular stress as a strategy for targeting cancer cells.

    10citations

    Google Scholar
  4. Pure and Applied Chemistry · 2017

    Anti-cancer agents and reactive oxygen species modulators that target cancer cell metabolism

    FT Ndombera

    Abstract

    A review of anti-cancer agents and reactive oxygen species modulators that act on altered metabolic pathways in cancer cells.

    8citations

    Google Scholar
  5. Journal of Bioinformatics and Computational Genomics · 2020

    Revisiting cheminformatics and mechanisms of action of chloroquine and hydroxychloroquine in targeting COVID-19

    FT Ndombera

    Abstract

    A cheminformatics re-examination of the proposed mechanisms of action of chloroquine and hydroxychloroquine in the context of COVID-19.

    4citations

    Google Scholar
  6. Cancer Causes & Control · 2022

    The role of infections in the causation of cancer in Kenya

    VC Tuei, GK Maiyoh, FT Ndombera

    Abstract

    An epidemiological study of the contribution of infectious agents to cancer causation in Kenya.

    2citations

    Google Scholar

Method

How we work

Every piece of work follows the same five steps, so a claim can be traced from question to score.

  1. 01

    Question

    A decision someone has to make, written down before any analysis begins.

  2. 02

    Evidence ledger

    Sources, dates and uncertainty recorded line by line, so every claim can be traced.

  3. 03

    Model

    Models are built and judged per task on quality, safety and cost, with a clinician or analyst in the loop.

  4. 04

    Pre-registered forecast

    Probabilities are published before the outcome is known.

  5. 05

    Score

    Once a forecast resolves, it is scored with the Brier score, whether it flatters us or not.

Questions

Frequently asked

What is Pawanax Research?

Pawanax Research is the research group of Pawanax AI. We study clinical AI and safety, African language intelligence, epidemic intelligence, forecasting, and the economics of health. The group is led by Dr. Fidelis Ndombera, PhD.

Can I download the papers?

Yes. Every paper in the library above can be downloaded as a PDF. Drafts that have not been published are not available.

Do you share your models and code?

We share methods and results: how we built and evaluated a system, and what it found. Proprietary models and production code remain private.

How can I collaborate?

Write to pawanax@pawanalife.com with the subject “Research collaboration” and describe the question you are working on. We reply to every serious proposal.

Our research supports clinicians and families. It does not replace a doctor, and urgent symptoms are escalated to human care.

Work on the question with us

Researchers, funders, public-health teams and journalists are welcome. Tell us what you are trying to find out.

Start a research collaboration